Regulon controlled by the GppX hybrid two component system inPorphyromonas gingivalis
نویسندگان
چکیده
منابع مشابه
A Two-Component System Regulates Hemin Acquisition in Porphyromonas gingivalis
Porphyromonas gingivalis is a Gram-negative oral anaerobe associated with infection of the periodontia. The organism has a small number of two-component signal transduction systems, and after comparing genome sequences of strains W83 and ATCC 33277 we discovered that the latter was mutant in histidine kinase (PGN_0752), while the cognate response regulator (PGN_0753) remained intact. Microarray...
متن کاملPorphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component system
Porphyromonas gingivalis possesses two distinct fimbriae. The long (FimA) fimbriae have been extensively studied. Expression of the fimA gene is tightly controlled by a two-component system (FimS/FimR) through a cascade regulation. The short (Mfa1) fimbriae are less understood. The authors have recently demonstrated that both fimbriae are required for formation of P. gingivalis biofilms. Here, ...
متن کاملMisR/MisS two-component regulon in Neisseria meningitidis.
Two-component regulatory systems are involved in processes important for bacterial pathogenesis. Inactivation of the misR/misS system in Neisseria meningitidis results in the loss of phosphorylation of the lipooligosaccharide inner core and causes attenuation in a mouse model of meningococcal infection. One hundred seventeen (78 up-regulated and 39 down-regulated) potential regulatory targets o...
متن کاملNew target genes controlled by the Bradyrhizobium japonicum two-component regulatory system RegSR.
RegSR-like proteins, members of the family of two-component regulatory systems, are present in a large number of proteobacteria in which they globally control gene expression mostly in a redox-responsive manner. The controlled target genes feature an enormous functional diversity. In Bradyrhizobium japonicum, the facultative root nodule symbiont of soybean, RegSR activate the transcription of t...
متن کاملThe Two-Hybrid System
The bait and prey fusions are co-expressed in yeast where a physical interaction between X and Y leads to the reconstitution of a functional transcription factor that binds to the promoter of a reporter gene (Fig.1). Consequently, transcription of the reporter gene is switched on. A protein-protein interaction is therefore translated into reporter gene activity which can be detected or measured...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Oral Microbiology
سال: 2012
ISSN: 2041-1006
DOI: 10.1111/omi.12007